Yes, there are many tankless units that are sold for whole house applications.
But you need to look at the specs on them. They all have a chart giving the flow rate and temperature rise.
So part of sizing is to look at the incoming water temperature in the winter.
There is a large difference in MI and FL and that can make a big difference in the performance of a given tankless.
And you need to look at the water demand (flow rate) of different appliances and tubs and showers that you have.
Then look at what could be expected in the largest combintation of usages.
BTW, it is hard to get numbers on the actual energy saving for a tankless.
So much depends on the usage patterns. Someone like myself, single and not using lots of HW, would save more than someone with a large family that uses water at all times of the day.
And the one study that I did see compared it with the government usage pattern that is used in testing for the energy factor. They said that it is not the pattern does not match any user groups.
And my gas rates are loaded with a relatively high fixed rate ($25/month) and low usage rates that although they offer a rebate I don't think that it would ever pay for itself.