It’s time to channel what you learned in elementary school science! If your toilet bowl is already filled to the brim, either empty out some of the water or be prepared for a little overflow. Next, pour one cup of baking soda and one cup of vinegar down the toilet drain. When the vinegar and baking soda combine, the natural chemical reaction will bubble up and loosen the clog. After about thirty minutes, follow up with some hot water and see if it drains. If it does, you're good to go. If it doesn't, repeat the process once more.